2016年3月7日 星期一

肌醇,妳 吃對了嗎?


今天要來談肌醇 (Inositol)與多囊(PCOS)
肌醇有多種同分異構物,可以把它想成是維他命C的左右旋(但這裡的肌醇不是鏡像異構物就是了)

在臨床上最常討論的是myo-inositol(以下稱MI)和D-Chiro-Inositol(以下稱DCI)。此兩種形式在體內會互相轉換,在大多數組織中MI佔比高達99%
圖片來源: wiki

目前臨床實驗證實肌醇可有效改善多囊性卵巢症狀,指的是MI。DCI則被指出,在多囊或是做IVF的女性當中,攝取高濃度DCI反而會降低卵子品質。*

既然已經知道多囊性卵巢要吃MI了,那該吃多少?吃哪個牌子?

量的部分,這篇review**提到2g或4g/天都沒有引發副作用,而4g是比2g更為有效的療法。

知道服用量了,那品牌呢??這篇2011年的paper***拿了市面上四個牌子的Myo-inositol去打HPLC測純度,結果顯示純度差異很大,並不是價錢越高的越純。
他們測試的四個品牌分別是Inofolic, Prepart, Inocomplex, Redestop

結果如下
Inofolic純度97.5%,Prepart 純度89.1%,其餘兩個則不到宣稱含量的八成。

你,肌醇吃對了嗎?

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參考文獻
*
Cheang KI, Baillargeon JP, Essah PA, et al. Insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator correlates with insulin sensitivity in women with polycystic ovary syndrome. Metabolism. 2008;57(10):1390 – 1397.

Isabella R, Raffone E. Does ovary need D-chiro-inositol. J Ovarian Res. 2012;5(1):14.

**
Dinicola, Simona, et al. "The rationale of the myo‐inositol and D‐chiro‐inositol combined treatment for polycystic ovary syndrome." The Journal of Clinical Pharmacology 54.10 (2014): 1079-1092.

***
Papaleo, E., et al. "Myo-inositol products in polycystic ovary syndrome (PCOS) treatment: quality, labeling accuracy, and cost comparison." European review for medical and pharmacological sciences 15 (2011): 165-174.

2 則留言:

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